How it All Started

How it Started. Why it Started...

It all began in Boston on a spring day in May 1990 when a group of young friends and scientists got together and started to discuss a simpler way to quantify DNA molecules.  Dr. John CN Wang (Princeton University), Dr. Kai Wu (Cornell Medical University) and Dr. Thomas Wang (University of Chicago) began a scientific effort to better understand and track the amplification process of polymerase chain reaction, particularly focusing on ways to tell when sequence alterations are induced at the molecular level. The basic function of the DNA molecule is to preserve its sequence and to replicate. In simple terms, DNA replication is the process by which DNA makes copies of itself in cell division. Cancerous growth occurs due to mutational error in the replicating process which causes cell division to continue uncontrollably. Stress in its various forms is proven to induce cancer causing changes in DNA.

three great dogs photoAs loving dog owners, these scientists knew that a huge percentage of dogs die from forms of cancer caused by environmental stress. Dr. Wang and Dr. Bing, well aware that a dog is unable to express feelings of stress, anxiety or depression, wanted to find a safe and fast method to indicate when the canine body is under duress and in a condition highly prone to develop cancer.

After years of extensive laboratory research, they found a very safe and easy way to detect when canine molecular DNA is under stress and is much more likely to become unbalanced during its cellular division process. Based on the discovery of a proprietary crossover hybridization mechanism across nucleic acid strands, they found a way to tell when molecular regulatroy processes are likely to fail.

Today they are proud to unveil this fast and easy, early cancer molecular diagnostic test, OncoGuarDx, in kit form for concerned pet owners. Thanks to this at-home kit, you will be able to quickly tell how your best friend is doing, allowing you to address any need for stress reduction or, if warranted, to seek immediate professional veterinary care, where your early diagnosis will be a priceless benefit in treatment.

Our Key Scientists

Dr. John CN Wang

Doctor Wang is a man with a very busy schedule both at the lab and at home. With a lifelong interest in molecular biophysics and oncology, Dr. Wang has dedicated himself towards advancing many unique studies in different sciences. That’s not the busy part of his life though!

He is a very dedicated father of two great kids, a family of fun and rowdy dogs, four rabbits and there is more! Dr. Wang also greatly enjoys exotic fish and has an aquarium full of them. Besides work, family and pets, John greatly enjoys losing himself in a good book, travel with family whenever possible, and singing. When the warm weather comes, you can see him losing himself in his garden.

Education: Princeton University, Ph. D.

Dr. Bing Ling

Since the start of her studies, Dr. Ling has always been fascinated with medicine and its effects on DNA. She often refers to this interest as “connecting the dots between DNA and medicine”. Clearly there is a lot there, but it is still a very subset of disciplines full of wonder and awe. Dr. Ling is an MD from JangXi Medical School.

Outside of her career Dr. Ling loves being a mom, and is a chef hobbyist. One of her unique abilities and hobbies is orchid cultivation. This is something many consider to be extremely difficult skill and Dr. Ling loves that challenge! Besides being a mom and a scientist, she also enjoys interior design and music.

Wait till You See What We did so far...

As a team of scientists who are heavily focused on creating something that will make our dogs lives better, its tough to “brag” about the things we have been able to accomplish in our decades of research.  But… we have found some truly remarkable things that advance different disciplines of science and medicine.  So why not show you a small list of some of the most significant scientific discoveries we have made so far!  

Key Scientific Achievements

  • Invent and realize nested quantitative polymerase chain reaction
  • Discover and first to realize serum cell free DNA test for prenatal diagnosis
  • Invent and realize quantitative fuzzy hybridization
  • First to realize high-resolution epigenetic bioage determination
  • First to realize at-home cfDNA stress test
  • First to elucidate the energetics of cancer genomic DNA
  • First to realize point-of-care cancer diagnosis